Researchers used AI to indirectly compare data from three randomized controlled trials looking at sotatercept or selexipag in pulmonary arterial hypertension (PAH). Their findings suggest that sotatercept may reduce PAH-related events more effectively than selexipag, although the inference is based on reconstructed, indirectly compared data. Read the Cureus article

This study looked at how to better detect pulmonary hypertension (PH) in people with interstitial lung disease (ILD), since PH often makes breathing problems, quality of life, and survival worse. Researchers found that combining several common tests—such as lung function tests, heart ultrasounds, and CT scans—was more helpful for identifying PH early than relying solely on a doctor’s overall impression. Certain signs, including low oxygen levels, enlarged pulmonary arteries, and changes in...

This study looked at which proteins and metabolic biomarkers might be associated with the development of high-altitude pulmonary hypertension (PH). Looking at data from China, from rat tissues, and from the UK biobank, the researchers identified four proteins and 11 metabolites and built what they describe as a "robust predictive model" to predict and prevent high-altitude pulmonary hypertension. Read the Journal of Cardiovascular Development and Disease article