Phase 2 clinical trial of sotatercept for Group 2 PH succeeds
- PHA Canada
- Nov 19, 2025
- 1 min read
Pulmonary hypertension (PH) due to heart failure -- Group 2 PH -- has, until now, been treated by treating the underlying heart failure. However, a recent Phase 2 clinical trial, called CADENCE, tried treating PH due to heart failure with preserved ejection fraction (HFpEF) with sotatercept. Phase 2 trials are small trials which look at the safety of a drug and at whether it seems to work.
Full data have not been published yet, but CADENCE successfully met its primary endpoint -- participants who took sotatercept showed a significant reduction in pulmonary vascular resistance after 24 weeks of treatment, compared to participants who received a placebo. Lower pulmonary vascular resistance means the heart needs to use less energy to pump blood through the lungs.
Because this Phase 2 trial was successful, a Phase 3 trial is planned. Phase 3 trials are larger trials which look at whether or not a drug treatment is better than the current standard treatment and whether the drug is reasonably safe. They are the last clinical trials before a manufacturer applies for drug approval.
While much work remains, the CADENCE results offer a welcome sign that new options for Group 2 PH may finally be within reach.
Wow, that's great news about the sotatercept trial! It's amazing how much progress is being made. Looking at all these health updates makes me want to organize my own photos, maybe I'll try photoeditai to make them look even better!
This is such exciting news for Group 2 PH patients! It's always amazing to see new treatments being explored. Speaking of new tools, I've been playing around with an ai image editor lately, and it's incredible what it can do for photos!
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Mathplayground reminds me how a clear framework makes hard topics easier, and this post does that for Group 2 PH and the CADENCE trial. A meaningful drop in pulmonary vascular resistance at 24 weeks is encouraging, especially since HFpEF-related PH has mostly meant “treat the heart failure and hope.”