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Faulty arginine metabolism contributes to cardiopulmonary dysfunction in thalassemia

is a major factor in acute pain episodes of sickle cell disease. A deficiency of nitric oxide.... has been identified in sickle cell disease and may contribute to episodes of bl
A research study of patients with thalassemia found that low bioavailability of the amino acid arginine may contribute to pulmonary hypertension – increased blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries. Pulmonary hyperte… http://www.phacanada.ca/en/news-and-events/newsfeed/faulty-arginine-metabolism-contributes-to-cardiopulmonary-dysfunction-in-thalassemia

Newsfeed: Potential Treatment For Pulmonary Hypertension

Researchers in the Faculty of Medicine & Dentistry at the University of Alberta are one step closer to a treatment for a deadly disease. Pulmonary arterial hypertension, which is high blood pressure in the lungs, currently has only a few treatment options… http://www.phacanada.ca/en/news-and-events/newsfeed/potential-treatment-for-pulmonary-hypertension

Patients with low pulmonary vascular resistance may benefit from complex procedure for PH

for patients with pulmonary hypertension in sickle cell disease More information
Patients with chronic pulmonary thromboembolic disease may benefit from pulmonary thromboendarterectomy (PTE), even if the patients don't have severe pulmonary hypertension, according to University of California, San Diego, researchers. The study wa… http://www.phacanada.ca/en/news-and-events/newsfeed/patients-with-low-pulmonary-vascular-resistance-may-benefit-from-complex-procedure-for-ph

CHMP Reaffirms Its Positive Opinion of Uptravi to Treat Pulmonary Arterial Hypertension

sickle cell disease
The Committee for Medicinal Products for Human Use (CHMP), the scientific board of the European Medicines Agency (EMA), has “readopted” its positive opinion in support of Actelion’s Uptravi (selexipag) as a treatment for pulmonary arterial hypertension (P… http://www.phacanada.ca/en/news-and-events/newsfeed/chmp-reaffirms-its-positive-opinion-of-uptravi-to-treat-pulmonary-arterial-hypertension

IV-delivered Stem Cells Show Potential as Pulmonary Hypertension Therapy, Rat Study Shows

IV delivery of stem cells to rats with pulmonary arterial hypertension (PAH) reduced the animals’ harmful lung blood vessel remodeling and improved their blood flow, a study reports. Researchers said the implication was that the stem cells could be use… http://www.phacanada.ca/en/news-and-events/newsfeed/iv-delivered-stem-cells-show-potential-as-pulmonary-hypertension-therapy-rat-study-shows

Professor finds likely key to cure for pulmonary hypertension

According to a recent Yale co-authored study that was conducted at the Yale School of Medicine, research on smooth muscle cell progenitors could be the key to finding a cure for pulmonary hypertension. Pulmonary hypertension is a disease in which patient… http://www.phacanada.ca/en/news-and-events/newsfeed/professor-finds-likely-key-to-cure-for-pulmonary-hypertension

Unproven Stem Cell Treatments for Lung Disease—An Emerging Public Health Problem

What are stem cells and how can they potentially be used in medicine?Stem cells are undifferentiated cells that have the ability to become specialized cells. They also are able to make more copies of themselves. There are different types of stem cells inc… http://www.phacanada.ca/en/news-and-events/newsfeed/unproven-stem-cell-treatments-for-lung-diseasean-emerging-public-health-problem

iPSCs Uncover Protective Pathways Against Carriers of BMPR2 Mutation

Contrary to what we learned in our high school biology classes, not all genetic diseases are easy to predict. Many of you may remember Punnett Squares, where we were able to determine the likelihood of a child having certain outcomes or diseases. While cy… http://www.phacanada.ca/en/news-and-events/newsfeed/ipscs-uncover-protective-pathways-against-carriers-of-bmpr2-mutation

A Common Stem Cell For The Heart And Lungs Reveals Intricacies Of Life On Land

A common stem cell in the heart and lung systems may explain the evolution of life — and related disease — on land. BY MATTHEW MIENTKA | JUL 22, 2013 11:51 AM EDT EMAIL PRINT 4 TEXT SIZE TEXT SIZE TEXT SIZE Tagsevolution The discovery of a co… http://www.phacanada.ca/en/news-and-events/newsfeed/2013-07-22-a-common-stem-cell-for-heart-and-lungs

Yale study provides a breath of hope for pulmonary hypertension patients

Most of us draw roughly 25,000 breaths a day without any thought. But for patients with pulmonary hypertension, a life-threatening increase in blood pressure in the lungs, even the smallest task can leave them gasping for air. A new study by researchers a… http://www.phacanada.ca/en/news-and-events/newsfeed/yale-study-provides-a-breath-of-hope-for-pulmonary-hypertension-patients

2017 04 01 Dinner Party to recognize our local PH Patients and families

A special Tribute evening to recognize the Ottawa Heart Institute and its world renowned PH Research Special Guest Speakers include: Dr. Duncan Stewart, Director of Research, Ottawa Heart Institute PH Clinic Dr. Lisa Mielniczuk, Ottawa Heart Institu… http://www.phacanada.ca/en/news-and-events/events-calendar/2017-04-01-dinner-party-to-recognize-our-local-ph-patients-and-families

Newsfeed: Gene regulation found to play role in pulmonary hypertension

he type that develops in some patients with sickle cell disease. In addition to showing altered B
http://www.phacanada.ca/en/news-and-events/newsfeed/newsfeed-gene-regulation-found-to-play-role-in-pulmonary-hyperte

TLR3 Immune Receptor Seen As a Promising Therapeutic Target in Rat Study

Stimulating the activity of an immune system receptor called TLR3 led to a reduction of pulmonary hypertension (PH) symptoms in a rat model of the disease, making TLR3 a promising therapeutic target for treating the condition in humans. Researchers sai… http://www.phacanada.ca/en/news-and-events/newsfeed/tlr3-immune-receptor-seen-as-a-promising-therapeutic-target-in-rat-study

Calcilytics Could be Used to Treat Idiopathic Pulmonary Arterial Hypertension

A recent study from Japan has shown that dividing cells involved in causing idiopathic pulmonary arterial hypertension (IPAH) may be stopped with a new type of drug called a calcilytic. The research could led to new treatments for IPAH. The study, titled … http://www.phacanada.ca/en/news-and-events/newsfeed/calcilytics-could-be-used-to-treat-idiopathic-pulmonary-arterial-hypertension

New mitochondrial research offers hope to those suffering serious disease

(Medical Xpress)—Queen's University professor Stephen Archer's (Department of Medicine) research has revealed that in serious human diseases (such as pulmonary hypertension, lung cancer, cardiac arrest and neurologic disease) the cell's power source, know… http://www.phacanada.ca/en/news-and-events/newsfeed/2013-12-6-new-mitochondrial-research-offers-hope

Stem Cells Derived from Human Umbilical Cord Blood Could Treat Pulmonary Arterial Hypertension

Conditioned medium from hUCB-MSCs in a PAH rat model leads to improved lung function in affected rats. A recently published paper in Journal of Pathology and Translational Medicine entitled “Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal … http://www.phacanada.ca/en/news-and-events/newsfeed/stem-cells-derived-from-human-umbilical-cord-blood-could-treat-pulmonary-arterial-hypertension

Research in the news: Scientists identify potential therapeutic target for pulmonary hypertension

Cardiovascular diseases are the leading cause of death worldwide. As a prime example, pulmonary hypertension is especially lethal, with one-half of patients dying within three years of being diagnosed. Yale researchers have uncovered a novel cell type tha… http://www.phacanada.ca/en/news-and-events/newsfeed/research-in-the-news-scientists-identify-potential-therapeutic-target-for-pulmonary-hypertension

PHA Canada is Pleased to Announce the 2018 Paroian Family PH Research Scholarship Award Recipient

The Pulmonary Hypertension Association of Canada (PHA Canada) is pleased to announce that the third recipient of the Paroian Family PH Research Scholarship is Dr. François Potus, a Postdoctoral Fellow at Queen’s University’s Department of Medicine in King… http://www.phacanada.ca/en/news-and-events/newsfeed/pha-canada-is-pleased-to-announce-the-2018-paroian-family-ph-research-scholarship-award-recipient

Newsfeed: Research update: what’s going on with Stem Cells and PH?

Angie KnottNational Manager, PHA Canada One of the sessions I had the pleasure of attending while at PHA USA’s 9th International Conference in California was the one titled “Stem Cells and PAH: Cause or cure?” with Dr. Duncan Stewart and Dr. David Langleb… http://www.phacanada.ca/en/news-and-events/newsfeed/research-update-what-s-going-on-with-stem-cells-and-ph

Reducing heart failure in pulmonary hypertension

An article published in Experimental Biology and Medicine (Volume 242, Issue 5, March, 2017) identifies a new signaling pathway that promotes heart failure in pulmonary hypertension. The study, led by Dr. Matthias Brock, from the Division of Pulmonology,… http://www.phacanada.ca/en/news-and-events/newsfeed/reducing-heart-failure-in-pulmonary-hypertension