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Drinking Nitrate-Rich Beetroot Juice May Improve NO Levels in PAH Patients, Small Trial Shows
Drinking nitrate-rich beetroot juice can improve the production of nitric oxide in patients with pulmonary arterial hypertension (PAH), a small clinical trial shows. Data from the trial was reported in the study, “Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension — results from BEET-PAH an exploratory randomized, double-blind, placebo-controlled crossover study,” published in the …
Why Chair Yoga for People With Pulmonary Hypertension?
Yoga has been practiced for thousands of years, and people who practice yoga have experienced the benefits. Today, yoga is more widely known and practiced, and has become an important part of therapy for a variety of medical conditions. One smaller pilot study in Canada in pulmonary arterial hypertension (PAH) patients revealed some potential at least short-term quality of life improvements as a result of participating in yoga. A 2008 study among…
TLR3 Immune Receptor Seen As a Promising Therapeutic Target in Rat Study
Stimulating the activity of an immune system receptor called TLR3 led to a reduction of pulmonary hypertension (PH) symptoms in a rat model of the disease, making TLR3 a promising therapeutic target for treating the condition in humans. Researchers said that using treatments to restore TLR3 activity, which is reduced in patients with PH, may become a new avenue to complement existing treatment strategies.
Not so rare: The fight for rare disease treatment
Rare diseases are by definition uncommon. But, collectively, rare diseases like Gaucher, Pompe, Fabry, and MPS (mucopolysaccharidosis) affect millions of Canadians. Many of these diseases can be very serious and even life-threatening, and yet, even when an effective treatment exists, obtaining prompt and affordable access to it can be a challenge in Canada. This is something that health care experts and advocates are working to change. “In rar…
(Sorta) Supportive, a Show About Teens With Chronic Illness, Could Be Coming Your Way
A new TV comedy series will chronicle the lives of a group of teenagers with chronic illnesses, according to Deadline. “(Sorta) Supportive” will include actors with chronic illnesses or those who have family members with chronic illnesses. Travis Flores, the show’s producer and writer, has cystic fibrosis and is the recipient of a double lung transplant. Flores is also an award-winning children’s book author. Most of the cast and crew either h…
Clinical Trial Expected in 2019 to Test Therapy C76 as Potential PAH Inhibitor
A clinical trial to study a therapy that may inhibit and possibly reverse vascular remodeling in pulmonary arterial hypertension (PAH) is expected to start enrolling patients in 2019. The medicine, C76, was shown to inhibit a gene called HIF-2? and to lead to reversal of PAH in animal models. The study reporting the findings, “Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in PAH with HIF-2? Inhibitor,” was published in t…
Géraldine Vitry - Paroian Family PH Research Scholarship
Vitry obtained a degree in Life Sciences in Cellular Biology and Physiology and a Master's degree in Therapies and Technologies with a special mention from the University of Paris 13 in France. In this context, she had the opportunity to work on the cystic development of the kidney in Renal Cyst and Diabetes (RCAD) pathology during a 2-month internship, then to study telomeres and their potential as a therapeutic target in cancers for 7 months. T…
Anti-cancer Therapy Sorafenib Reverses PAH in Rat Model, Study Reports
Treatment with the approved anti-cancer medication sorafenib reversed pulmonary arterial hypertension (PAH) and cardiopulmonary remodeling (CPR) in a rat model, according to a new study. The findings suggest that a low-dose therapy with this compound may be successful in PAH treatment, the Japanese research team suggests.
Karima Habbout - Mohammed Family PH Research Scholarship
Pulmonary arterial hypertension (PAH) is a progressive disease affecting the lungs and hearts of patients and can often lead to heart failure. Inside the arteries of the lungs, vessels undergo a deep remodelling that obstructs the artery, preventing proper blood flow from the heart to the lungs. PAH is similar to cancer, in that the cells inside the pulmonary arteries continue to multiply due to a resistance to cell death. This similarity make…
Bellerophon Announces Results of Interim Analysis of Phase 3 INOvation-1 Study Evaluating INOpulse® for Treatment of Pulmonary Arterial Hypertension
Bellerophon Therapeutics, Inc. (Nasdaq:BLPH) (“Bellerophon” or the “Company”), a clinical-stage biotherapeutics company, today announced that the Data Monitoring Committee (DMC) has completed its pre-specified interim analysis from the first 75 enrolled subjects completing 16-weeks of treatment in the Phase 3 INOvation-1 study evaluating INOpulse® for the treatment of pulmonary arterial hypertension (PAH).
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