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New Genetic Cause of Pulmonary Hypertension Identified
NEW YORK, NY (July 25, 2013) — Columbia University Medical Center (CUMC) scientists have identified new genetic mutations that can cause pulmonary arterial hypertension (PAH), a rare fatal disease characterized by high blood pressure in the lungs. The mutations, found in the gene KCNK3, appear to affect potassium channels in the pulmonary artery, a mechanism not previously linked to the condition. Cell culture studies showed that the mutations' e…
Novel Pulmonary Hypertension Drug From Bayer Shows Modest Promise In Phase 3 Trials
A new drug appears to have promising– but not game-changing– effects in people with two forms of pulmonary hypertension. Riociguat, a soluble guanylate cyclase stimulator under development by Bayer, is thought to have vasodilating, antiproliferative and antifibrotic effects. Ball-and-stick model of the riociguat molecule... Results of two phase 3 placebo-controlled trials were published today in the New England Journal of Medicine. CHEST-1 …
A Common Stem Cell For The Heart And Lungs Reveals Intricacies Of Life On Land
A common stem cell in the heart and lung systems may explain the evolution of life — and related disease — on land. BY MATTHEW MIENTKA | JUL 22, 2013 11:51 AM EDT EMAIL PRINT 4 TEXT SIZE TEXT SIZE TEXT SIZE Tagsevolution The discovery of a common embryonic stem cell in the cardiopulmonary system may help to explain the evolution of life on land, as well as the pathology of pulmonary hypertension — a disease affecting both the lungs a…
Film informs about rare scleroderma
By Curtis Skinner, Inquirer Staff Writer POSTED: July 21, 2013 Sandy Selfridge was one in a thousand. In April 2009, she was diagnosed with scleroderma, a rare autoimmune disease involving the skin. By September, at age 58, she was gone. Her death led Christy McCaffrey, her daughter, to produce a documentary about the disease. The 45-minute film, Project Scleroderma: Beneath the Surface, which took two years and $40,000 to make, is narrated …
Cancer survivor awaits double lung transplant
Jeanine Doiron of Mount Pearl says she is “terribly homesick” while staying at Toronto General Hospital, where the 34-year-old is waiting for a double lung transplant to treat pulmonary hypertension, an ailment she has lived with for four years. “Toronto certainly isn’t St. John’s,” said Doiron with emotion in her voice. 2009 was a tumultuous year for Doiron. Her diagnosis for pulmonary hypertension came only a few months before doctors infor…
Progress made in understanding Pulmonary Arterial Hypertension
July 17, 2013 Source: News Medical The next step has been made into isolating the origin of cells linked to the progressive disorder Pulmonary Arterial Hypertension. Further strides have been made into isolating the origin of cells that could lead to a greater understanding of what goes into the development of our blood circulating systems. University of Lincoln Life Sciences academic Dr Rajiv Machado, with colleagues from the Univers…
Heart failure: New treatment option makes heart 'softer'
July 12, 2013 Source: Medical Xpress Heart failure with concomitant pulmonary hypertension is a growing health problem with a high mortality rate, above all in older people. The cardiologist Diana Bonderman from the University Department of Internal Medicine II at the MedUni Vienna, as the author of a multinational phase II study, has demonstrated the effectiveness of a substance that sticks to the so-called nitric oxide pathway and makes th…
Pulmonary Denervation Shows Promise for Resistant Pulmonary Hypertension
July 16, 2013 Source: TCTMD Key Points: Pilot study tests pulmonary artery denervation for idiopathic pulmonary hypertension Treatment reduces pulmonary pressure, increases functional capacity at 3 months Procedure could open new avenue for patients with few options, outside experts say By Yael L. Maxwell Tuesday, July 16, 2013 A novel pulmonary artery denervation approach is safe and effective for patients with idiopathic pulmona…
Gender, sex hormones and pulmonary hypertension
July 8, 2013 Source: Pulmonary Circulation - Official Journal of the Pulmonary Vascular Research Institute Abstract: Most subtypes of pulmonary arterial hypertension (PAH) are characterized by a greater susceptibility to disease among females, although females with PAH appear to live longer after diagnosis. While this "estrogen paradox" of enhanced female survival despite increased female susceptibility remains a mystery, recent progress ha…
Rare illness makes life a struggle
July 6, 2013 Jenna Lowe was a dancer and a swimmer, but now she uses a mobility scooter to get to her matric classes at Herschel, and can’t walk any distance without becoming dizzy and weak. Every day, the 18-year-old Claremont girl breathes oxygen through a tube, swallows warfarin to prevent her blood from clotting and takes imitation Viagra designed to dilate the vessels in her lungs. But it’s bosentan that will help prolong her life. …
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