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Protein in 'good cholesterol' may be a key to treating pulmonary hypertension
Oxidized lipids are known to play a key role in inflaming blood vessels and hardening arteries, which causes diseases like atherosclerosis. A new study at UCLA demonstrates that they may also contribute to pulmonary hypertension, a serious lung disease that narrows the small blood vessels in the lungs. Using a rodent model, the researchers showed that a peptide mimicking part of the main protein in high-density lipoprotein (HDL), the so-called…
New Report Identifies Key Features in Systemic Sclerosis
Systemic sclerosis (SSc) is a disease that affects multiple organs, with the heart being frequently affected and correlating with a poor outcome for the patient. Different heart structures can be affected leading to pericardial disease, arrhythmias, conduction system abnormalities, direct myocardial disease such as pulmonary arterial hypertension, myositis, cardiac failure, cardiac fibrosis, coronary artery diseases and, sometimes, primary valvul…
Novel Nitric Oxide Delivery System May Someday Improve PH Treatments
GeNo LLC, a pharmaceutical company developing a line of innovative nitric oxide drug products, is currently testing next-generation inhaled nitric oxide (NO) drug delivery systems for use in both hospital and outpatient settings that could come to impact treatments for those with pulmonary hypertension. Nitric oxide is a naturally occurring cellular signaling molecule that can function as an important biological regulator and has a crucial role …
New Pediatric PAH Goals For Treatment Could Improve Patient Outcomes
A team of researchers from the University Medical Center Groningen in Holland, has identified three baseline variables that can become treatment goals in children suffering with pulmonary arterial hypertension (PAH). PAH is rare in infants, however, it is a severe condition that rapidly deteriorates if left untreated. Pediatric PAH can be idiopathic PAH (IPAH), heritable PAH, or associated with congenital heart disease (PAH-CHD). Common symptom…
Systemic Sclerosis Patients At Higher Risk To Develop PAH
A team of over twenty researchers recently found that patients with systemic sclerosis are at high risk to develop pulmonary arterial hypertension(PAH). The study, published in the Seminars in Arthritis & Rheumatism, set out to understand the natural history of pulmonary hypertension (PH) in systemic sclerosis (Ssc), through a prospective longitudinal cohort study they called Pulmonary Hypertension Assessment and Recognition of Outcomes in Scler…
Tom Lantos Innovation in Community Service Awards Given by Pulmonary Hypertension Association to Advance Awareness of Rare Lung Disease
The Pulmonary Hypertension Association (PHA) has awarded 13 committed community activists funding for projects to raise awareness of pulmonary hypertension (PH) – a rare, debilitating disease of the lungs that affects the functioning of the heart and can lead to right heart failure. Without treatment, mean survivability is only 2.8 years. Known as the Tom Lantos Innovation in Community Service Awards, the grants were established to create opport…
Pulmonary Hypertension in Infants: Subcutaneous Treprostinil?
Subcutaneous treprostinil (SCTre) is an effective second-line therapy for former premature infants who have chronic lung disease and severe pulmonary hypertension, according to Dina J. Ferdman, MD, from the Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Medical Center, College of Physicians and Surgeons, New York City, and colleagues. They published the results of their case series of 5 infants online June 30 and …
Severe pulmonary arterial hypertension secondary to lupus in the emergency department: Proactive intense care associated with a better short-term survival
Chen Y, et al. – The aim of the current prospective study is to initiate a proactive intense care strategy on severe systemic lupus erythematosus (SLE)–PAH patients in the emergency setting and evaluate its impact on the short–term survival. Therefore, the study suggest that proactive care and combination PAH–targeted treatment can improve short–term survival of severe SLE–PAH in the emergency setting. Methods The proactive intense care str…
Hidden Origins Of Pulmonary Hypertension Revealed by Network Modeling
In a groundbreaking study, researchers from Brigham and Women’s Hospital (BWH) have identified a related family of molecules believed to be a major root cause of pulmonary hypertension, a deadly vascular disease with undefined origins. This is one of the first studies to leverage advanced computational network modeling to decipher the molecular secrets of this complex human disease. The study is published online June 24, 2014 in The Journal of…
Gender–dependent Influence of Endogenous Estrogen in Pulmonary Hypertension.
Abstract Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models that display female susceptibility estrogens may play a causative role. Objectives: To clarify the influence of endogenous estrogen and gender in PH and assess the therapeutic potential o…
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