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United Therapeutics and DEKA Sign Agreement for New PAH Remodulin Delivery System
United Therapeutics Corporation has signed an agreement with DEKA Research & Development Corp., to continue the development of a breakthrough technology for the subcutaneous delivery of the Remodulin (treprostinil) Injection. The device is expected to offer a potential treatment option for patients who suffer from pulmonary arterial hypertension (PAH) and improve administration of Remodulin. The breakthrough subcutaneous delivery technology wi…
Researchers Discover Protein That Can Prevent Pulmonary Hypertension-Related Heart Failure
RegeneRx Biopharmaceuticals, Inc. announced a recent study where company’s scientists demonstrated that Thymosin beta 4 (TB4) can reduce or even prevent heart failure in a pulmonary hypertension mouse model. The study, entitled “Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy,” was published in the journal Plos One. Pulmonary hypertension (PH) is characterized by increased blood p…
Rescue Treatment with L-Citrulline Inhibits Hypoxia-induced Pulmonary Hypertension in Newborn Pigs
Abstract Rationale: Infants with cardiopulmonary disorders associated with hypoxia develop pulmonary hypertension. We previously showed that initiation of oral L-citrulline prior to and continued throughout hypoxic exposure, improves nitric oxide (NO) production and ameliorates pulmonary hypertension in newborn piglets. Rescue treatments, initiated after the onset of pulmonary hypertension, better approximate clinical strategies. Mechanisms by w…
Raising awareness of Pulmonary Hypertension
The 3rd annual 6 Minute Walk for Breath took place at the Bradford West Gwillimbury Leisure Centre, Nov. 20, to raise awareness and funds for research, as well as for the education and advocacy efforts of the Pulmonary Hypertension Association of Canada. With your help, we are spreading the word about this rare lung disease, in the hope of reducing the time between the onset of symptoms, and the diagnosis and treatment of PH. This year, we are…
There is hope for those with PH
When Joan Nemeth could not climb stairs or vacuum her living room without getting out of breath, she knew something was seriously wrong. Diagnosed five years ago with pulmonary hypertension, the Vernon resident was a non-smoker who had always enjoyed good health. “I had no idea what it was, but I was under a doctor’s care and I expected a diagnosis,” she said. “One morning I woke up and I could not make it to the bathroom because I couldn’t…
PH Awareness at the Leisure Centre
Pulmonary Hypertension is a rare, debilitating, progressive and potentially fatal disease, affecting up to 10,000 Canadians – although it’s hard to know for certain. Early symptoms are so general, that they are often misdiagnosed by attending physicians. Breathlessness, fatigue, irregular heartbeat, fainting, chest pain – the signs of PH may be interpreted as anything from a heart condition, to Asthma. In Pulmonary Hypertension, the arterie…
Novel Surgical CTEPH Treatment Approach Cures Disease
Vanderbilt Heart & Vascular Institute (VHVI) is offering a novel and specialized surgical approach for treating patients suffering from chronic thromboembolic pulmonary hypertension (CTEPH), a form of pulmonary hypertension (PH) that can cause breathing difficulties, acute pulmonary embolism, or blood clots in the lung. Even though the condition is rare and often misdiagnosed, several efforts have been made to support patients, including the crea…
Magnetic resonance imaging may aid detection of pulmonary hypertension
1. Among patients with suspected pulmonary artery hypertension, vortical blood flow measurement by magnetic resonance (MR) imaging agreed closely with direct pressure measurement by during right heart catheterization. 2. The duration of vortical blood flow corresponded linearly with the degree of pulmonary artery hypertension and served as a specific and non-invasive method for its detection. Evidence rating: 3 (Average) Study Rundown: P…
PH Research Corner: Developing Novel Therapies for Pulmonary Arterial Hypertension.
In this corner, you will find the latest advancements in the field of PAH therapeutics. But before we get into that, I think it would be useful to start with information on how new therapies are tested before getting to the patients. The process starts with a screen of different chemicals. In PAH, we know that cells in blood vessels in the lungs are hyper-proliferative, meaning that they multiply too quickly, very similarly to a cancerous cell…
Navigating caregiving, chronic conditions a strain on Canadians, according to new survey
For many Canadians, finding their way through the healthcare system is a daunting task. In fact, 81 per cent of Canadians find the system too complicated, and 78 per cent agree that navigating it is a challenge, according to a recent survey commissioned by CARP and the Sheridan Centre for Elder Research, and made possible by Amgen Canada. When asked what presents the biggest challenges to navigating the system, Canadians identified management of …
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