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SteadyMed and Cardiome Partner To Commercialize PAH Therapy Trevyent Outside The U.S.
SteadyMed Ltd., a pharmaceutical company developing therapies for both high value and orphan diseases with unmet parenteral delivery needs, and Cardiome Pharma Corp. have recently announced an exclusive agreement for Cardiome to market Trevyent in specific markets outside the United States if Trevyent receives approval to treat pulmonary arterial hypertension (PAH) in those regions. The license agreement stipulates that SteadyMed will receive $12…
Significant Number of SLE Patients May Have Pulmonary HTN
About 8% of patients with systemic lupus erythematosus (SLE) have pulmonary hypertension (PH), and serum uric acid (UA) has reasonable accuracy for predicting PH, according to a study published in the June issue of the International Journal of Rheumatic Diseases. Ki-Jo Kim, MD, from the Catholic University of Korea in Seoul, and colleagues conducted a prospective cross-sectional study of 114 patients with SLE to examine the point prevalence of…
Researchers discover treatment for Pulmonary Arterial Hypertension
According to the team, genetic evidence dating back to the year 2000 indicated that the absence or reduced activity of a particular protein, bone morophogenetic protein type II receptor (BMPR-II), leads to PAH. A research funded by the British Heart Foundation (BHF) and carried out at the University of Cambridge has found that a protein targeting the effects of a faulty gene could offer the first treatment targeting the major genetic cause of Pu…
‘This could be a real game-changer’: protein points to cure for life-limiting disease
Doctors treating boy victim of PAH raise hopes for a drug to beat a condition that leaves patients breathless, exhausted and prone to heart attacks.
Triciribine drug may reverse progression of pulmonary fibrosis and pulmonary hypertension
Researchers at the University of Georgia have discovered that the drug triciribine may reverse or halt the progression of pulmonary fibrosis and pulmonary hypertension, two respiratory diseases that are almost invariably fatal. They published their findings recently in the British Journal of Pharmacology. Pulmonary fibrosis occurs when lung tissue becomes scarred, leading to loss of lung function and reduced oxygen supply to the blood. Pulmona…
Reseach Corner: role of endothelin-1 in PAH and drugs used for blocking its function
In this issue, we will address some questions regarding PH therapy, more specifically, the role of endothelin-1 in PAH and drugs used for blocking its function.
A Wish Come True: Creating Hope For Kids With Life-threatening Illnesses
Isabelle Platnar is nine years old and has been diagnosed with pulmonary hypertension, a type of high blood pressure that affects the arteries in the lungs and the right side of her heart. Pulmonary hypertension is a serious illness that becomes progressively worse and can be fatal. Despite this, Isabelle Platnar’s mother, Sarah Platnar, describes Isabelle as “having an infectious spirit, she is optimistic and has a positive attitude.”
PAH Admissions Reduced With Initial Combo Tx
Starting pulmonary arterial hypertension patients out on the combination of ambrisentan and tadalafil significantly reduced hospitalizations related to the condition compared with monotherapy, a trial showed.
Mitral Valve Surgery Identified As Potential Treatment For PAH Secondary to Mitral Valve Disease
In a recent study entitled “An excellent result of surgical treatment in patients with severe pulmonary arterial hypertension following mitral valve disease,” authors analyzed recent outcomes and mortality rates for patients with pulmonary arterial hypertension who underwent mitral valve surgery. They observed a significant decrease in the number of deaths and suggest that mitral valve surgery is an effective treatment and relatively safe in this…
Researchers Find That Estrogen Receptor Alpha is Linked to Pulmonary Hypertension Development
Researchers in Glasgow, UK, publish findings revealing that a specific receptor of the hormone estrogen is involved in the development of pulmonary hypertension. The findings may offer new insights into why PH disproportionately affects women.
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