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Researchers identify new drug target for serious heart and lung condition
A gene has been identified that sheds new light on a potentially fatal heart and lung condition and could lead to a new treatment. The findings, published today in Nature, indicate that a new treatment for pulmonary arterial hypertension (PAH), a debilitating disease, could be produced by suppressing this gene. Pulmonary hypertension occurs when blood vessels in the lung constrict and become stiffer, putting a strain on the heart as it tries t…
Researchers Publish The Most Comprehensive Data Ever on PAH Genes
An international group of scientists has comprehensively characterized the genetics of pulmonary arterial hypertension (PAH). This new information could ultimately help clinicians treat the disease based on individual traits and genetic makeup. This is the most complete set of genetic data that has been collected about the disease to date.
Bellerophon phase II win could mean new portable option in PAH
Bellerophon Therapeutics Inc.'s inhaled nitric oxide seems poised to become a key add-on, orphan therapy in pulmonary arterial hypertension (PAH) and, if all goes well, could also end up the only approved therapy in pulmonary hypertension when associated with chronic obstructive pulmonary disease (COPD).
Research Corner: New PH therapies, pathways and clinical trials
In this issue of the Research Corner, some of the novel PH therapies under development are discussed. I will also explain the different target pathways for PH treatments, and the different research stages. Currently approved PH treatments aim to increase levels of natural lung vasodilation, leading to opening (dilation) of blood vessels. Vasodilators work directly on the walls of your arteries, preventing the muscles from tightening and the w…
Stem cell therapy shows promise in small clinical trial for rare lung disease
Canadian researchers have published promising results of the first clinical trial in the world of a genetically-enhanced stem cell therapy for pulmonary arterial hypertension (PAH). This rare and deadly disease mainly affects young women, and is characterized by very high pressure in the arteries supplying blood to the lungs. In some cases, PAH is caused by a defective gene, but in many cases the cause is unknown. Currently available drugs ca…
New Sound Wave-Based Method for Assessing Heart Function in PAH Shows Promise in New Study
A new imaging method that uses sound waves could help in assessing heart damage in people with pulmonary arterial hypertension (PAH), according to a recent study that appeared June 26 in the Journal of Cardiovascular Ultrasound. PAH refers to high blood pressure of the lungs. It can be associated with different diseases, such as arthritis, or can be of unknown cause (idiopathic). According to the American Lung Association, “PAH worsens over ti…
Faulty arginine metabolism contributes to cardiopulmonary dysfunction in thalassemia
A research study of patients with thalassemia found that low bioavailability of the amino acid arginine may contribute to pulmonary hypertension – increased blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries. Pulmonary hypertension is a common problem in patients with thalassemia, an inherited blood disorder that results in abnormal formation of hemoglobin, the protein in red blood cells that carries oxygen. The…
Massachusetts General Team Generates Therapeutic Nitric Oxide from Air with an Electric Spark
Treatment with inhaled nitric oxide (NO) has proven to be life saving in newborns, children and adults with several dangerous conditions, but the availability of the treatment has been limited by the size, weight and complexity of equipment needed to administer the gas and the therapy's high price. Now a research team led by the Massachusetts General Hospital (MGH) physician who pioneered the use of inhaled nitric oxide has developed a lightweigh…
No Ronald McDonald House for sick adults
Sudbury woman waits in Toronto for a double-lung transplant There is no Ronald McDonald House for sick adults who must travel, and live, in Toronto to receive their medical care.
'I'm addicted to helping'
A Grimsby woman has learned first hand the reward of giving is much better than that of receiving. Sharon Williamson, a special constable with the Hamilton Police Service, is giving away her fifth trip to Niagara Falls. This time, she is looking to grant a getaway for two to a leader in the community, someone who gives back and inspires others. Williamson was inspired to find the most deserving Ontarian by Albertans Cody and Eva Borek, who …
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